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P35221-B21 — Storage Datasheet

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HPE · DRIVE SFF
WHAT YOU NEED TO KNOW
SAS backplane accepts SATA drives (not vice versa) Buy with tray when possible — saves cost vs separate tray
ALWAYS ASK: "Does it come with tray/caddy?"
PRODUCT OVERVIEW

HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD. The unit ships in a SFF form factor suitable for standard rack-mount installations. Available through authorized enterprise resellers and TPM (Third Party Maintenance) channels.

Verify compatibility with your specific system configuration before ordering.

WHERE IT FITS
SFF BAY→ P35221-B21
SPECIFICATIONS
Part NumberP35221-B21
ManufacturerHPE
Form FactorSFF
Capacity480GB
COMPONENT DIAGRAM
LATCH 480GB SAS — P35221-B21 SAS CONN WITH TRAY — HOT-PLUG READY Tray: See server gen 480GB SAS — P35221-B21 BARE DRIVE — NO LATCH Needs caddy/tray to install 2.5" (70 x 100mm) SFF 2.5" DRIVE | 480GB | SAS — Always ask: "Does it come with tray/caddy?" | Tray PN varies by server generation TITLE SFF 2.5" DRIVE PN P35221-B21 CAP 480GB SAS
KEY FEATURES
•
SFF Form Factor
•
480GB Capacity
TYPICAL APPLICATIONS
  • Enterprise storage arrays and SANs
  • Direct-attached storage (DAS) expansion
  • Database tier storage (OLTP, OLAP)
  • Virtual machine datastore expansion
  • Backup-to-disk and disaster recovery targets
  • Content delivery and media streaming storage
VERIFIED SUBSTITUTES & CROSS-REFERENCES 11
P18432-B21Compatible
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
compatible
P18477-001Compatible
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
compatible
MK000480GXNXBCompatible
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SSD - Bare Drive
compatible
MK000480GXPRTCompatible
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SSD - Bare Drive
compatible
MK000480GXWBKCompatible
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SSD - Bare Drive
compatible
P18432-H21Compatible
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
compatible
LIFECYCLE
StatusUNKNOWN
Availability—
RoHS CompliantEAR99ESD SensitiveNot HAZMAT
THIS PART SUBSTITUTES FOR 11
MK000480GXNXBSUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
MK000480GXPRTSUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
MK000480GXWBKSUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
P18432-B21SUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
P18432-H21SUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
P18432-K21SUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
P18432-X21SUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
P18442-001SUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
P18477-001SUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
P35223-001SUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
P35266-001SUBSTITUTE
HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD
HPE
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FREQUENTLY ASKED QUESTIONS
What is P35221-B21?
P35221-B21 is a HP 480Gb SATA 6G Mixed Use Digitally Signed Multi Vendor SFF SC SSD manufactured by HPE.
What parts can replace P35221-B21?
There are 11 known substitutes for P35221-B21: P18432-B21, P18477-001, MK000480GXNXB and 8 more. Substitute compatibility should be verified for your specific system.
Is P35221-B21 still available?
P35221-B21 is currently Unknown.
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Last verified: September 2026