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P18462-B21 — Network Technical Data

HPE · NIC ADAPTER
WHAT YOU NEED TO KNOW
RJ45 = copper (needs CAT6) | SFP+ = fiber (needs transceiver) FLR = FlexibleLOM (HPE integrated) — NOT standard PCIe
Bracket height MUST match chassis — Full Height (2U) vs Low Profile (1U)
PRODUCT OVERVIEW

HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet Controller (Mellanox ConnectX-4 Lx). Available through authorized enterprise resellers and TPM (Third Party Maintenance) channels. Verify compatibility with your specific system configuration before ordering.

WHERE IT FITS
P18462-B21
SPECIFICATIONS
Part NumberP18462-B21
ManufacturerHPE
Interface25GbE
Capacity25GB
BROWSE HPE MACHINES
ProLiant DL360 Gen10 ProLiant DL380 Gen10 ProLiant BL460c Gen10 ProLiant DL380 Gen9 ProLiant DL360 Gen9 3PAR StoreServ 8450 ProLiant BL685c G7 3PAR StoreServ 8400 3PAR StoreServ 8440 3PAR StoreServ 8200 MSA 2052 SAN Storage ProLiant BL460c Gen9
All HPE machines and parts
COMPONENT DIAGRAM
NIC CTRL PHY 0 PHY 1 ROM VRM 25GbE 25GbE LINK ACT PCIe x8 ~167 mm NETWORK ADAPTER | 2-PORT 10GbE | 25GbE | Full Height PCIe x8 | Link/Activity LEDs | PXE boot ROM TITLE NIC ADAPTER PN P18462-B21 MFR HPE HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.
KEY FEATURES
•
25GbE Interface
•
25GB Capacity
TYPICAL APPLICATIONS
  • Data center top-of-rack switching
  • High-speed server interconnects (10G/25G/40G/100G)
  • Storage network fabric (iSCSI, FCoE)
  • Campus and branch network infrastructure
  • Firewall and security appliance connectivity
  • WAN edge and SD-WAN deployments
SUBSTITUTES & CROSS-REFERENCES 3
817753-B21CompatiblePARTNER
HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet Controller (Mellanox ConnectX-4 Lx)
compatible
840140-001CompatiblePARTNER
HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet Controller (Mellanox ConnectX-4 Lx)
compatible
817751-001CompatiblePARTNER
HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet Controller (Mellanox ConnectX-4 Lx)
compatible
LIFECYCLE

No lifecycle data available.

THIS PART SUBSTITUTES FOR 3
817751-001SUBSTITUTE
HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet Controller (Mellanox ConnectX-4 Lx) for DX Servers
HPE
817753-B21SUBSTITUTE
HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet Controller (Mellanox ConnectX-4 Lx) for DX Servers
HPE
840140-001SUBSTITUTE
HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet Controller (Mellanox ConnectX-4 Lx) for DX Servers
HPE
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FREQUENTLY ASKED QUESTIONS
What is P18462-B21?
P18462-B21 is a HP NIC 640SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet Controller (Mellanox ConnectX-4 Lx) manufactured by HPE.
What parts can replace P18462-B21?
There are 3 known substitutes for P18462-B21: 817753-B21, 840140-001, 817751-001. Substitute compatibility should be verified for your specific system.
Is P18462-B21 still available?
P18462-B21 is currently Unknown.
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PartsTable commercial catalog: edition Unified commercial catalog snapshot through 2026-09-28, edition date not on file, retrieved 2026-09-28.