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P18461-B21 — HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx)

HPE · NIC ADAPTER
PRODUCT OVERVIEW

P18461-B21: HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx).

HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx). Available through authorized enterprise resellers and TPM (Third Party Maintenance) channels. Verify compatibility with your specific system configuration before ordering.

SPECIFICATIONS
Part NumberP18461-B21
ManufacturerHPE
Interface25GbE
Capacity25GB
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COMPONENT DIAGRAM
NIC CTRL PHY 0 PHY 1 ROM VRM 25GbE 25GbE LINK ACT PCIe x8 ~167 mm NETWORK ADAPTER | 2-PORT 10GbE | 25GbE | Full Height PCIe x8 | Link/Activity LEDs | PXE boot ROM TITLE NIC ADAPTER PN P18461-B21 MFR HPE HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-
KEY FEATURES
•
25GbE Interface
•
25GB Capacity
TYPICAL APPLICATIONS
  • Data center top-of-rack switching
  • High-speed server interconnects (10G/25G/40G/100G)
  • Storage network fabric (iSCSI, FCoE)
  • Campus and branch network infrastructure
  • Firewall and security appliance connectivity
  • WAN edge and SD-WAN deployments
SUBSTITUTES & CROSS-REFERENCES 4
817749-B21CompatiblePARTNER
HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx)
compatible
840139-001CompatiblePARTNER
HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx)
compatible
817747-001CompatiblePARTNER
HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx)
compatible
817750-B21CompatiblePARTNER
HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx) FIO
compatible
LIFECYCLE

No lifecycle data available.

THIS PART SUBSTITUTES FOR 4
817747-001SUBSTITUTE
HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx) for DX Servers
HPE
817749-B21SUBSTITUTE
HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx) for DX Servers
HPE
817750-B21SUBSTITUTE
HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx) for DX Servers
HPE
840139-001SUBSTITUTE
HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx) for DX Servers
HPE
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FREQUENTLY ASKED QUESTIONS
What is P18461-B21?
P18461-B21 is a HP NIC 640FLB-SFP28 10/25GbE 2-Port PCI-E-3.0x8 Ethernet FlexibleLOM (Mellanox ConnectX-4 Lx) manufactured by HPE.
What parts can replace P18461-B21?
There are 4 known substitutes for P18461-B21: 817749-B21, 840139-001, 817747-001 and 1 more. Substitute compatibility should be verified for your specific system.
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PartsTable commercial catalog: edition Unified commercial catalog snapshot through 2026-09-28, edition date not on file, retrieved 2026-09-28.