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846510-B21 ✓ Verified by PartsTable
HPE · DRIVE LFF
WHAT YOU NEED TO KNOW
SAS backplane supports SATA, not vice versa NL-SAS = SAS protocol at nearline (7.2K) speed — NOT SATA
Gen8 LFF tray ≠ Gen10 tray — different screw holes
PRODUCT OVERVIEW

The HP 846510-B21 HPE 6TB SATA 6G Midline 7.2K LFF (3.5in) SC 1yr Wty Digitally Signed Firmware HDD Manufacturer: HP ItemCondition: REF Model: Alternative Part Numbers: is a HPE hard disk drive designed for enterprise environments demanding consistent performance and data integrity. The unit ships in a LFF form factor suitable for standard rack-mount installations. Available through authorized enterprise resellers and TPM (Third Party Maintenance) channels.

Verify compatibility with your specific system configuration before ordering.

WHERE IT FITS
LFF BAY→ 846510-B21
SPECIFICATIONS
Part Number846510-B21
ManufacturerHPE
Form FactorLFF
Capacity6TB
Speed7.2K RPM
COMPONENT DIAGRAM
RELEASE LATCH 6TB NL-SAS 7.2K RPM 846510-B21 HPE NL-SAS INTERFACE INTERPOSER SAS drive in SATA tray? Check board compatibility 3.5" (101.6 x 146mm) LFF 3.5" DRIVE | 6TB | NL-SAS 7.2K RPM NL-SAS uses SAS protocol at 7.2K RPM | SAS backplane supports SATA, not reverse Tray generation matters | Gen8 LFF tray differs from Gen10 TITLE LFF 3.5" DRIVE PN 846510-B21 MFR HPE
KEY FEATURES
•
LFF Form Factor
•
6TB Capacity
•
7.2K RPM Speed
TYPICAL APPLICATIONS
  • Enterprise storage arrays and SANs
  • Direct-attached storage (DAS) expansion
  • Database tier storage (OLTP, OLAP)
  • Virtual machine datastore expansion
  • Backup-to-disk and disaster recovery targets
  • Content delivery and media streaming storage
VERIFIED SUBSTITUTES & CROSS-REFERENCES 3
846608-001Compatible
HP 6Tb SATA 6G 7.2K 512n Digitally Signed MDL LFF SC HDD
compatible
846508-001Compatible
HP 6Tb SATA 6G 7.2K 512n Digitally Signed MDL LFF HDD - Bare Drive
compatible
MB6000GVYYUCompatible
HP 6Tb SATA 6G 7.2K 512n Digitally Signed MDL LFF HDD - Bare Drive
compatible
LIFECYCLE
StatusUNKNOWN
Availability—
RoHS CompliantEAR99ESD SensitiveNot HAZMAT
THIS PART SUBSTITUTES FOR 3
MB6000GVYYUSUBSTITUTE
HP 6Tb SATA 6G 7.2K 512n Digitally Signed MDL LFF SC HDD
HPE
846508-001SUBSTITUTE
HP 6Tb SATA 6G 7.2K 512n Digitally Signed MDL LFF SC HDD
HPE
846608-001SUBSTITUTE
HP 6Tb SATA 6G 7.2K 512n Digitally Signed MDL LFF SC HDD
HPE
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FREQUENTLY ASKED QUESTIONS
What is 846510-B21?
846510-B21 is a HP 846510-B21 HPE 6TB SATA 6G Midline 7.2K LFF (3.5in) SC 1yr Wty Digitally Signed Firmware HDD Manufacturer: HP ItemCondition: REF Model: Alternative Part Numbers: manufactured by HPE.
What parts can replace 846510-B21?
There are 3 known substitutes for 846510-B21: 846608-001, 846508-001, MB6000GVYYU. Substitute compatibility should be verified for your specific system.
Is 846510-B21 still available?
846510-B21 is currently Unknown.
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Validated with multiple authoritative sources, including Government, OEM, and Certified sources.
Last verified: July 2026