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781581-006 — Storage Datasheet

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HPE · DRIVE SFF
WHAT YOU NEED TO KNOW
SAS backplane accepts SATA drives (not vice versa) Buy with tray when possible — saves cost vs separate tray
ALWAYS ASK: "Does it come with tray/caddy?"
PRODUCT OVERVIEW

HP 781581-006 internal hard drive 300 GB 10000 RPM 128 MB 2.5" SAS. The unit ships in a SFF form factor suitable for standard rack-mount installations. Available through authorized enterprise resellers and TPM (Third Party Maintenance) channels.

Verify compatibility with your specific system configuration before ordering.

WHERE IT FITS
SFF BAY→ 781581-006
SPECIFICATIONS
Part Number781581-006
ManufacturerHPE
Form FactorSFF
Capacity300GB
COMPONENT DIAGRAM
LATCH 300GB SAS — 781581-006 SAS CONN WITH TRAY — HOT-PLUG READY Tray: See server gen 300GB SAS — 781581-006 BARE DRIVE — NO LATCH Needs caddy/tray to install 2.5" (70 x 100mm) SFF 2.5" DRIVE | 300GB | SAS — Always ask: "Does it come with tray/caddy?" | Tray PN varies by server generation TITLE SFF 2.5" DRIVE PN 781581-006 CAP 300GB SAS
KEY FEATURES
•
SFF Form Factor
•
300GB Capacity
TYPICAL APPLICATIONS
  • Enterprise storage arrays and SANs
  • Direct-attached storage (DAS) expansion
  • Database tier storage (OLTP, OLAP)
  • Virtual machine datastore expansion
  • Backup-to-disk and disaster recovery targets
  • Content delivery and media streaming storage
VERIFIED SUBSTITUTES & CROSS-REFERENCES 12
785410-001Compatible
HP 300GB SAS 12G 10k 512n SFF Sc HDD
compatible
768788-001Compatible
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
compatible
781581-005Compatible
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
compatible
836625-B21Compatible
HP 300GB SAS 12G 10k 512n SFF Sc HDD
compatible
836790-001Compatible
HP 300GB SAS 12G 10k 512n SFF Sc HDD
compatible
846257-B21Compatible
HP 300GB SAS 12G 10k 512n SFF Sc HDD
compatible
LIFECYCLE
StatusUNKNOWN
Availability—
RoHS CompliantEAR99ESD SensitiveNot HAZMAT
THIS PART SUBSTITUTES FOR 15
EG000300JWBHRSUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
EG000300JWEBFSUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
EG0300JEHLVSUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
768788-001SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
781581-005SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
785067-B21SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
785410-001SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
836625-B21SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
836790-001SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
846257-B21SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
846265-B21SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
846287-001SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
846291-001SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
862119-001SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
869714-001SUBSTITUTE
HP 300Gb SAS 12G 10K 512n SFF HDD - Bare Drive
HPE
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FREQUENTLY ASKED QUESTIONS
What is 781581-006?
781581-006 is a HP 781581-006 internal hard drive 300 GB 10000 RPM 128 MB 2.5" SAS manufactured by HPE.
What parts can replace 781581-006?
There are 12 known substitutes for 781581-006: 785410-001, 768788-001, 781581-005 and 9 more. Substitute compatibility should be verified for your specific system.
Is 781581-006 still available?
781581-006 is currently Unknown.
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Last verified: September 2026