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759221-004 — Storage Datasheet

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HPE · DRIVE LFF
WHAT YOU NEED TO KNOW
SAS backplane supports SATA, not vice versa NL-SAS = SAS protocol at nearline (7.2K) speed — NOT SATA
Gen8 LFF tray ≠ Gen10 tray — different screw holes
PRODUCT OVERVIEW

HP 759221-004 internal hard drive 450 GB 15000 RPM 3.5" SAS. The unit ships in a LFF form factor suitable for standard rack-mount installations. Available through authorized enterprise resellers and TPM (Third Party Maintenance) channels.

Verify compatibility with your specific system configuration before ordering.

WHERE IT FITS
LFF BAY→ 759221-004
SPECIFICATIONS
Part Number759221-004
ManufacturerHPE
Form FactorLFF
Capacity450GB
COMPONENT DIAGRAM
RELEASE LATCH 450GB NL-SAS 7.2K 759221-004 HPE NL-SAS INTERFACE INTERPOSER SAS drive in SATA tray? Check board compatibility 3.5" (101.6 x 146mm) LFF 3.5" DRIVE | 450GB | NL-SAS 7.2K NL-SAS uses SAS protocol at 7.2K RPM | SAS backplane supports SATA, not reverse Tray generation matters | Gen8 LFF tray differs from Gen10 TITLE LFF 3.5" DRIVE PN 759221-004 MFR HPE
KEY FEATURES
•
LFF Form Factor
•
450GB Capacity
TYPICAL APPLICATIONS
  • Enterprise storage arrays and SANs
  • Direct-attached storage (DAS) expansion
  • Database tier storage (OLTP, OLAP)
  • Virtual machine datastore expansion
  • Backup-to-disk and disaster recovery targets
  • Content delivery and media streaming storage
VERIFIED SUBSTITUTES & CROSS-REFERENCES 8
759210-B21Compatible
HP 450GB SAS 12G 15k 512n SFF Sc HDD
compatible
759547-001Compatible
HP 450GB SAS 12G 15k 512n SFF Sc HDD
compatible
744995-002Compatible
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
compatible
748385-002Compatible
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
compatible
759202-002Compatible
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
compatible
EH0450JDXBBCompatible
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
compatible
LIFECYCLE
StatusUNKNOWN
Availability—
RoHS CompliantEAR99ESD SensitiveNot HAZMAT
THIS PART SUBSTITUTES FOR 20
B9F31ASUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
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DF0450B8054SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
DF0450BAERHSUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
EF0450FARMVSUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
EF0450FATFESUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
EH0450JDXBBSUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
EH0450JDYTKSUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
EH0450JEDHDSUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
J9F41ASUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
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375874-017SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
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375874-018SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
454228-003SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
454232-B21SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
454234-B21SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
454274-001SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
454275-001SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
480528-002SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
516810-002SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
516810-004SUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
AP871ASUBSTITUTE
HP 450Gb SAS 12G 15K 512n SFF HDD - Bare Drive
HPE
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FREQUENTLY ASKED QUESTIONS
What is 759221-004?
759221-004 is a HP 759221-004 internal hard drive 450 GB 15000 RPM 3.5" SAS manufactured by HPE.
What parts can replace 759221-004?
There are 8 known substitutes for 759221-004: 759210-B21, 759547-001, 744995-002 and 5 more. Substitute compatibility should be verified for your specific system.
Is 759221-004 still available?
759221-004 is currently Unknown.
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Last verified: September 2026