PartsTable
Technical Data Sheet
PartsTable / SERVERS / 753221-B21
753221-B21 ✓ Verified by PartsTable
HP · DIMM
WHAT YOU NEED TO KNOW
2Rx4 = Dual Rank ×4 chip width (standard server) RDIMM = Registered (servers) | LRDIMM = Load-Reduced (max density)
DDR3 ≠ DDR4 ≠ DDR5 — physically incompatible (notch position)
PRODUCT OVERVIEW

The HP 16GB (1x16gb) 2Rx4 PC4-2133P-R Memory is a HP memory module engineered for enterprise server and workstation platforms requiring validated, high-reliability memory. Available through authorized enterprise resellers and TPM (Third Party Maintenance) channels. Verify compatibility with your specific system configuration before ordering.

WHERE IT FITS
753221-B21
SPECIFICATIONS
Part Number753221-B21
ManufacturerHP
Capacity16GB
Speed2133MHz
COMPONENT DIAGRAM
ECC 16GB 2Rx4 PC4 2133MHz RDIMM HP NOTCH ~133.35 mm DDR4 RDIMM | 16GB | 2133MHz | PC4 Notch position = DDR4 generation | DDR3/DDR4/DDR5 physically incompatible RDIMM = Registered (servers) | LRDIMM = Load-Reduced | UDIMM = Unbuffered TITLE DDR4 RDIMM PN 753221-B21 MFR HP 16GB 2133MHz
KEY FEATURES
•
16GB Capacity
•
2133MHz Speed
TYPICAL APPLICATIONS
  • Server memory expansion for virtualization workloads
  • Database performance optimization (in-memory computing)
  • VDI and remote desktop session hosting
  • High-performance computing (HPC) clusters
  • Mail server and collaboration platform scaling
  • Application server tier expansion
VERIFIED SUBSTITUTES & CROSS-REFERENCES 12
726719-B21Compatible
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
compatible
774172-001Compatible
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
compatible
752369-081Compatible
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
compatible
752369-08SCompatible
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
compatible
752369-281Compatible
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
compatible
752369-581Compatible
HP 16GB PC4-2133P-R ECC Reg Dr X4 Cas-15 Dimm - Intel - WS
compatible
LIFECYCLE
StatusUNKNOWN
Availability—
RoHS CompliantEAR99ESD SensitiveNot HAZMAT
THIS PART SUBSTITUTES FOR 20
J9P83AASUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
J9P83ATSUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
726719-B21SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
752369-081SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
752369-08SSUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
752369-281SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
752369-581SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
752369-EF1SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
752369-M81SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
752369-MH1SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
752369-T81SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
753221-201SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
774172-001SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
790111-001SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
807818-B21SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
810744-B21SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
812221-001SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
817547-081SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
847826-B21SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
850086-001SUBSTITUTE
HP 16Gb PC4-2133P-R ECC REG DR x4 CAS-15 DIMM - Intel v3 - G9
HPE
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FREQUENTLY ASKED QUESTIONS
What is 753221-B21?
753221-B21 is a HP 16GB (1x16gb) 2Rx4 PC4-2133P-R Memory manufactured by HP.
What parts can replace 753221-B21?
There are 12 known substitutes for 753221-B21: 726719-B21, 774172-001, 752369-081 and 9 more. Substitute compatibility should be verified for your specific system.
Is 753221-B21 still available?
753221-B21 is currently Unknown.
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✓ Validated with multiple authoritative sources, including Government, OEM, and Certified sources.
PartsTable Design LLC · partstable.com
Last verified: July 2026